[Mneumonic] Cyclosporin

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cyclosporin


calcineurin inhibitor
  • inhibit calcium dependent second messenger signals in T cells following activation via TCR
  • inhibits IL-2 production by T-lymphocytes
  • adverse effects (4HRT)
4 H - hyperkalemia, hypertension, hypertrichosis, hypertrophy of gum
R - renal toxicity (chronic interstitial nephritis)
T – tremor


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